As you could probably imagine, polycystic kidney disease is a genetic disorder that affects the kidneys by way of multiple cysts. Slowly, the cysts overtake healthy kidney tissue and can cause irreversible damage. As the tissue becomes damaged, kidneys lose their functionality and ability to filter waste from our blood. Polycystic Kidney Disease (PKD) can develop cysts on other internal organs, including the liver — another powerhouse of filtration for our bodies.